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Name:
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NATALIE DEMO
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Date of Birth:
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Coriell ID:
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DEMONAT
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Lab Accessioning Number:
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DEMONAT
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Ordering Physician:
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Gender:
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Female
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Date Collected:
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Date Received:
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Date of Report:
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11/11/2013
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SLCO1B1 and Simvastatin Response
These results were generated in a CLIA-approved laboratory as part of the Coriell Personalized Medicine Collaborative research study. Results take into account 4 genetic variants in the SLCO1B1 gene, known to contribute to how the liver metabolizes simvastatin (Zocor®). This report reflects this participant’s liver uptake status predicted based on genetic testing but does not reflect whether they are currently taking simvastatin (Zocor®).
The CPMC has a genetic counselor who is available to assist with report interpretation at no charge. For questions please contact us at
cpmcgc@coriell.org
or by phone at 888-580-8028. Participants may schedule an appointment with our board certified genetic counselor by logging into their web portal account and clicking on “request an appointment”. For general information about the CPMC please visit our website
cpmc.coriell.org.
This research report includes all data included in the clinical report as well as supplemental drug specific interpretations and educational material. Please see the report that follows for the official clinical report.
Your combination of genetic variant results is listed below in yellow.
Your SLCO1B1* result is:
SLCO1B1*1/*1
(Normal liver uptake activity)
| VARIANTS TESTED | YOUR RESULT1 | REFERENCE VALUE |
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rs72559745 (SLCO1B1*1)
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AA
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A A
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rs56061388 (SLCO1B1*3)
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TT
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T T
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rs4149056 (SLCO1B1*5)
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TT
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T T
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rs55901008 (SLCO1B1*6)
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TT
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T T
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1When your variant result for all SLCO1B1 variants tested are the same as the reference, the combined genetic result is called SLCO1B1*1/*1. In some cases your combined genetic result may be uncertain.
Other variants, not currently included in this CPMC test may influence this result and interpretation.
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Your combination of genetic variants indicates that you have normal SLCO1B1 liver uptake activity.
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People with normal SLCO1B1 liver uptake activity are expected to have a typical response to a standard dose of simvastatin.
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Reduced SLCO1B1 activity
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Reduced Liver Uptake Activity
0
out of 100 people
High risk of myopathy when taking a 40 mg/day or higher dose of simvastatin (Zocor®).
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Intermediate Liver Uptake Activity
8
out of 100 people
Moderately increased risk of myopathy when taking a 40 mg/day or higher dose of simvastatin (Zocor®).
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Normal SLCO1B1 activity
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Normal Liver Uptake Activity
92
out of 100 people
Expected to have a typical response to a standard dose of simvastatin (Zocor®).
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Genetic Risk Factors
Genetic variants, or changes, in a gene called SLCO1B1 can affect the way your liver metabolizes simvastatin (Zocor®).
Some people with certain genetic variants may be at increased risk for myopathy (muscle weakness) when taking a 40 mg/day or higher dose of simvastatin (Zocor®). These individuals may need a lower dose or a different statin drug.
Non-Genetic Risk Factors
Many factors affect how your body responds to medications.
Non-genetic factors include: diet, lifestyle, medical history and interactions between medications.
Gene Affecting Simvastatin (Zocor®) Metabolism:
SLCO1B1
Types of Variants in SLCO1B1
There are many variants in the SLCO1B1 gene. A number system has been created to name common combinations of variants. Some variant combinations have not been assigned a number yet. Other combinations of variants cannot be assigned a number with certainty. We all have 2 copies of every gene; when possible, you will have a SLCO1B1 result with two numbers.
Example: SLCO1B1*1/*3
Your personal result can be found
by clicking on the RESULTS tab
above.
| Medication/Medication Type | Examples |
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Antifungal medications
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Itraconazole/Sporanox®, ketoconazole/Nizoral® , posaconazole/Noxafil®, voriconazole/VFEND®
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Macrolide antibiotics
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erythromycin/E-mycin®, clarithromycin/Biaxin®, telithromycin/Ketek®
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Blood thinners
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warfarin/Coumadin®, Athrombin®
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HIV protease inhibitors
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Atazanavir/Reyataz®, darunavir/Prezista®, fosamprenavir/Lexiva®, indinavir/Crixivan®, nelfinavir/Viracept®, ritonavir/Norvir®, saquinavir/Invirase®, tipranavir/Aptivus®
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Hepatitis C medications
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boceprevir/Victrelis®, telaprevir/Incivek®
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Blood pressure medications
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verapamil/Calan®, diltiazem/Cardizem®, amlodipine/Norvasc®
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Anti-arrhythmia medications
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dronedarone/Multaq®, amiodarone/Cordarone®
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gemfibrozil
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Lopid®
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cyclosporine
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Neoral®, Sandimmune®, Gengraf®
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danazol
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Danocrine®
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ranolazine
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Ranexa®
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For a list of medications that may affect your response to simvastatin (Zocor®),
click here.
To check for interactions between simvastatin (Zocor®) and medications you are taking,
click here.
The following foods, vitamins, and supplements are known to interact with simvastatin (Zocor®):
Grapefruit and grapefruit juice
- Avoid eating grapefruit or drinking grapefruit juice while taking simvastatin (Zocor®).
- Drinking grapefruit juice while taking simvastatin (Zocor®) increases the risk of liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle.
- Tell your doctor right away if you have unexplained muscle pain, tenderness, or weakness while taking simvastatin (Zocor®), especially if you also have a fever or dark colored urine.
For a list of foods, vitamins, and supplements that may interact with simvastatin (Zocor®),
click here.
Share these results with your healthcare providers.
Print Report
DO NOT MAKE CHANGES TO ANY MEDICATION WITHOUT TALKING TO YOUR HEALTHCARE PROVIDERS.
Result Limitations
- This result alone does NOT predict your total response to simvastatin (Zocor®).
- Other factors such as body weight, various health conditions, and other medications may impact an individual’s response to simvastatin (Zocor®).
- There may be other genetic variants within the SLCO1B1 gene which influence response to simvastatin (Zocor®) but are not included in this test.
- There may be other genetic variants in the SLCO1B1 gene for which response to simvastatin (Zocor®) has not been documented and/or validated in multiple studies.
- There may be genetic variants in other genes that influence response to simvastatin (Zocor®)
- This result reflects published data available at the time this gene-drug pair was approved by the CPMC Informed Cohort Oversight Board (March 2012). The information provided may change as new scientific information becomes available.
- Although rare, it is possible that you may receive an incorrect result; 100% accuracy of reported results cannot be guaranteed.
- Occasionally, we will be unable to interpret one or more gene variants. In this case you will not receive a result for those variants and in some cases your drug response cannot be interpreted. It is expected that you will receive results for about 95% of variants approved by the
Pharmacogenetics Advisory Group (PAG)
and
Informed Cohort Oversight Board (ICOB).
- Every effort will be made to provide you with risk information based on your reported race/ethnicity. However, data may not be available for all races/ethnicities. Please see your individual results to determine which race/ethnicity the data is based on.
Test Limitations
DNA-based testing is highly accurate, however there are many sources of potential error including: mis-identification of samples, rare technical errors, trace contamination of PCR reactions, and rare genetic variants that interfere with analysis. This test or one or more of its components was developed and its performance characteristics determined by the Coriell Institute for Medical Research. It has not been approved by the Food and Drug Administration (FDA). The FDA has determined that such approval is not necessary. The Coriell Institute is regulated under the Clinical Laboratory Improvement Amendments (CLIA) of 1988 as qualified to perform high-complexity testing.
Methods
References
- Bailey KM, et al. Circ Cardiovasc genet 2010; 3:276-285.
- Donnelly LA, et al. Clin. Pharmacol Ther 2011; 89:210-216.
- Group SC, et al. NEJM 2008; 359:789-799.
- Ho RH, et al. Gastroenterol 2006, 130:1793-1806.
- Ho RH, et al. Pharmacogenet Genomics 2007; 17:647-656.
- Igel M, et al. Clin Pharmacol Ther 2006; 79:419-426.
- Kameyama Y, et al. Pharmacogenet Genomics 2005, 15:513-522.
- Kivisto KT, Niemi M Pharmaceutical research 2007; 24:239-247.
- Lee E, et al.Clin Pharmacol Ther 2005; 78:330-341.
- Lee YJ, et al. Inter J Clin Pharmacol Ther 2010; 48:36-45.
- Mwinyi J, et al. Clin Pharmacol Ther 2004; 75:415-421.
- Niemi M, et al. Pharmacogenet 2004; 14:429-440.
- Niemi M, et al. Pharmacogenet Genomics 2005; 15:303-309.
- Niemi M Pharmacogenomics 2007; 8:787-802.
- Nishizato Y, et al. Clin Pharmacol Ther 2003; 73:554-565.
- Pasanen MK, et al. Pharmacogenet Genomics 2006; 16:873-879.
- Pasanen MK, et al. Pharmacogenomics 2008; 9:19-33.
- Takane H, et al. J Hum Genet 2006; 51:822-826.
- Thompson JF, et al. Pharmacogenomics J 2005; 5:352-358.
- Tirona RG, et al. J biol chem 2001; 276:35669-35675.
- Voora D, et al. JACC 2009; 54:1609-1616.
Test Methodology
Saliva samples were collected using Oragene DNA Collection Kits (DNA Genotek) and DNA was extracted manually according to the manufacturer’s instructions or automatically using a DNAdvance Kit (Agencourt). Purified DNA was quantified using UV absorbance at 260 nm. One microgram of the resulting DNA from each sample was used as template in the Affymetrix DMET Plus GeneChip assay. Data analysis was performed using Affymetrix DMET Console software.
To view your clinical report,
click here.
The clinical report contains the lab generated testing information and does not include all the content in the research study report.
[Risk interpretation based on Coriell's SLCO1B1/Simvastatin Activity Genotype Version 1 (November 2013)]
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