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CYP2C19 and Clopidogrel (Plavix®) Response

What is clopidogrel (Plavix®)?

Clopidogrel, sold under the brand name Plavix®, is an anti-platelet medication that prevents platelets, a type of cell found in the blood, from sticking together. When platelets stick together they can form clots which block the flow of blood.
Clopidogrel Plavix®
Image from: www.drugs.com

What is CYP2C19?

Some medications are metabolized (broken down or activated) by enzymes. Variants in the genes coding for these enzymes may cause your body to metabolize a medication more quickly or more slowly than normal. These variants can affect how well the medication works, and the risk of side effects. CYP2C19 is a gene that contains the instructions for making an enzyme which metabolizes many different types of drugs. Some examples of drugs that are affected by CYP2C19 include the anti-platelet drug clopidogrel and the anti-ulcer, proton pump inhibitor drug, omeprazole, commonly known as Prilosec.

Are there other factors that can affect how clopidogrel (Plavix®) works?

Many factors affect how your body will respond to a medication. Non-genetic factors include interactions between different drugs you may be taking, interactions between drugs and your medical history, and interactions between drugs and your lifestyle.

Can CYP2C19 affect my response to any other drugs?

In addition to clopidogrel, your genetic results for CYP2C19 can affect your response to other drugs. Different drugs can be processed in different ways by the body. Because of these differences, the metabolizer status does not always predict the same response for all drugs, even when those drugs are metabolized by that same gene.

Example:

CYP2C19 metabolizes clopidogrel. Poor metabolizers may not respond to that drug and may need an alternative treatment.
CYP2C19 metabolizes many other drugs in addition to clopidogrel. Metabolizer status for one drug may not predict the same response to other drugs.

For a list of other drugs that may interact with CYP2C19 click here.

Talk to your healthcare providers about all of the medications (both over the counter and prescription) as well as any supplements that you are taking.

What does the CPMC Test for?

The CPMC tests for 8 variants in the CYP2C19 gene. Your personal result will be displayed in the form of a table on the RESULT tab within your personal report. Your result interpretation can be found on a separate INTERPRETATION tab.

For More Information?

References
1. http://drugtopics.modernmedicine.com/drugtopics/data/articlestandard/drugtopics/252010/674969/article.pdf

This report provides information about the way you may react to the drug clopidogrel (Plavix®).

Please share this information with your healthcare providers.
If you are taking clopidogrel, this information may be useful to your doctor.

If you are not currently taking clopidogrel this information may affect future prescribing decisions.