Multi-variant Genetic Risk

There are several factors that contribute to your risk for health conditions like diabetes and heart disease. The Coriell Personalized Medicine Collaborative (CPMC) research study provides participants with personalized risk reports based on one or more genetic variants, plus family history and lifestyle risk factors (like smoking, exercise habits, etc.) whenever possible.

For some health conditions, the CPMC will use multiple genetic variants to estimate your genetic risk. While this will allow for a better estimate of genetic risk than is possible using only a single genetic variant, these multi-variant risk reports will not represent your complete genetic risk for a condition. This is because there are additional genetic variants that are not included in our calculations, as some genetic variants have yet to be discovered, others have an uncertain association with disease, and some are not captured by our testing.

Multi-variant CPMC Reports

Multi-variant CPMC reports look very similar to CPMC single genetic variant reports. On the "Results-Risk Summary" page a single green disc represents your relative risk for the condition due to the combination of genetic variants that you have. The interpretation for your combination of genetic variants is provided in the summary table below the graph. You will also see your risks for the condition due to your family history (purple disc) and your lifestyle factors (blue discs) whenever possible.
variant-risk-discs 
While the graph looks the same for both the single genetic variant and mulitvariant CPMC reports, the interpretation language for each is slightly different. On CPMC single variant reports, genetic variant relative risk is your risk compared to individuals who do not have any copies of the individual risk or protective genetic variant that was tested. On CPMC multi-variant reports, genetic variant relative risk is your risk compared to that of an average risk individual.

The "About-Genetic Variants" tab of a CPMC mulitvariant report will provide you with more information about each of the individual genetic variants that the CPMC study included in the multi-variant genetic risk estimate.

As you can see in the example table below, a multi-variant report may include both "risk variants" that are associated with an increased risk for developing the condition and "protective variants" that are associated with a lower risk of developing the condition.
multi-variant-pancreatic-cancer-version-1 
All CPMC participants will receive a mulitvariant genetic risk estimate for a condition based on the same group of genetic variants. As always, all CPMC participants will receive a risk report for each health condition or drug-gene pair included in the study regardless of whether or not they are at increased risk for the condition, or whether or not they are taking that specific drug.

In some cases, you may not receive a genetic risk estimate. The CPMC is not able to provide a genetic risk estimate if a result for one or more of the genetic variants included in a multi-variant report is not able to be determined by our laboratory. However, participants will be able to see the relative risk values associated with each individual genetic variant of a mulitvariant report by clicking on the "Clinical Report" tab.