The CPMC Study and Thiopurines

What Does the CPMC Test For?

The CPMC evaluates 4 variants in the TPMT gene associated with low TPMT activity and altered thiopurine drug response. Your personal result will be displayed in the form of a table on the YOUR GENETIC RESULT tab within your personal report. Your result interpretation can be found on a separate YOUR RESULT INTERPRETATION tab.

Sample Report

In addition to the YOUR GENETIC RESULTS tab, which will show your personal result for each variant tested, you will be provided with an interpretation (found on the YOUR RESULT INTERPRETATION tab). The interpretation will give you information about how your personal genetic results will impact your predicted response to thiopurine drugs. In some cases this information will not be known.

Sample Report

CPMC Test and Report Limitations
It is important to note that CPMC testing alone cannot fully predict your response to thiopurines or any other drug or class of drugs. Other factors like body weight, other health conditions, and other medications may also influence the way a person will respond to thiopurines and other drugs. It is possible that you may have other genetic variants that occur in the TPMT gene that are not tested by the CPMC. Also, it is possible that you may have variants in other genes that influence your response to thiopurines.