The CPMC Study and Periodontitis

What Does the CPMC Test For?

The CPMC looked for the presence or absence of Periodontitis Variant 1 (rs1143634) in the IL1B gene. This is one variant out of many that can influence the risk of periodontitis. Each individual inherits 2 copies of every variant, 1 from each parent. Below are the possible results for this variant.

Having one or two copies of the risk variant may increase your risk of periodontitis. This result does not cause periodontitis and does not confirm a diagnosis of periodontitis. Having two copies of the non-risk variant does not rule out the risk of developing periodontitis in the future.

CPMC Periodontitis Genetic Variant 1 (rs1143634)

The rs1143634 (G>A) variant is found in the IL1B gene. This variant has been found to increase the risk of periodontitis among Caucasians.

Possible Periodontitis Genetic Variant 1 Results

Result data may not be available for all races or ethnicities. Sample data for Caucasian individuals is shown below.

Result frequencies and genetic variant risk results are obtained from Nikolopoulos et al. J Clin Periodontol 2008; 35(9):754-767.

People with one or two copies of the risk variant (G,A or A,A) are compared to people with no copies of the risk variant (G,G) to determine relative risk. A relative risk greater than 1.0 indicates an increased risk.