The CPMC Study and Migraine Headaches

What Does the CPMC Test For?

The CPMC looked for the presence or absence of Migraine Variant 1 (rs13208321) in the FHL5 gene on chromosome 6q16.1. This is one variant out of many that can influence the risk of migraine headaches. Each individual inherits 2 copies of every variant, 1 from each parent. Below are the possible results for this variant.

Having one or two copies of this genetic risk variant may increase your risk of having migraine headaches. This result does not cause migraine headaches and does not confirm a diagnosis of migraine headaches. Having zero copies of the risk variant does not rule out the risk of developing migraine headaches in the future.

CPMC Migraine Genetic Variant 1 (rs13208321)

The rs13208321 (G>A) variant is found in the FHL5 gene on chromosome 6q16.1. This variant influences protein function and has been found to increase the risk of migraine headaches1.

Possible Migraine Genetic Variant 1 Results
migraine-headache-cpmc

Result frequencies obtained on December 15, 2015 from: http://browser.1000genomes.org/Homo_sapiens/Variation/Explore?r=6:96859854-96860854;source=dbSNP;v=rs13208321;vdb=variation;vf=8113289.

Genetic variant risk results are obtained from: Anttila V., et al. (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat. Genet. 45(8):912-919.

People with one or two copies of the risk variant (G,A or A,A) are compared to people with no copies of the risk variant (G,G) to determine relative risk. A relative risk greater than 1.00 indicates an elevated risk.

Page References

1. Anttila V., et al. (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat. Genet. 45(8):912-919.