The United States Food and Drug Administration (FDA) recognizes the following drugs as being affected by the CYP2C19 gene:
  • Talk to your doctor or request an appointment with a CPMC genetic counselor to discuss the impact of your personal genetic results on the following drugs.
  • CYP2C19 can have different effects on different drugs. Any interpretation or recommendations regarding increases, decreases or changes in drug dosing apply only to the drug specified.
  • There may be other drugs affected by CYP2C19 that have not been recognized by the FDA at the time that this list was created or last updated.
  • There may be other genes, in addition to CYP2C19 that also influence the metabolism of the drugs listed below.
  • DO NOT MAKE ANY CHANGES TO ANY MEDICATION YOU ARE TAKING WITHOUT TALKING TO YOUR HEALTH CARE PROVIDER.
Brand Name Generic Name Treatment Area Use FDA Label Recommendation
SOMA Carisoprodol Rheumatology To treat pain/stiffness from muscle spasms No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
Celexa Citalopram Psychiatry To treat depression The maximum dose should be limited to 20 mg/day in patients who are CYP2C19 poor metabolizers.
Lexapro Escitalopram Psychiatry To treat depression & anxiety No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
ONFI Clobazam Neurology To treat seizures For CYP2C19 poor metabolizers, the starting dose should be 5 mg/day and dose titration should proceed slowly according to weight.
Plavix Clopidogrel Cardiovascular To prevent blood clots BLACK BOX WARNING: Consider alternative treatment or treatment strategies in patients identified as CYP2C19 poor metabolizers.
Valium or
Diastat
Diazepam Psychiatry To treat anxiety No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
Silenor, Zonalon, Prudoxin Doxepin Psychiatry Oral use to treat insomnia, depression & nerve pain. Topical use to treat itching. No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
YAZ Drospirenone and ethinyl estradiol Reproductive Birth control No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
Nexium Esomaprazole Gastro-enterology To treat reflux No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
VIMPAT Lacosamide Neurology To treat seizures No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
Viracept Nelfinavor Antiviral To treat viral infections No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
ACIPHEX Rabeprazole Gastroenterology To treat reflux No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
Dilantin Phenytoin Neurology To treat seizures No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
Effient Prasugrel Cardiology To prevent blood clots No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
Brilinta Ticagrelor Cardiology To treat reflux No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
VFEND Voriconazole Antifungal To treat serious fungal infections No specific recommendation for action based on CYP2C19 genotype is given in the drug label.
Updated 11/11/16