The United States Food and Drug Administration (FDA) recognizes the following drugs as being affected by the CYP2C19
gene:
- Talk to your doctor or request an appointment with a CPMC genetic counselor to discuss the impact of your personal genetic results on the following drugs.
- CYP2C19 can have different effects on different drugs. Any interpretation or recommendations regarding increases, decreases or changes in drug dosing apply only to the drug specified.
- There may be other drugs affected by CYP2C19 that have not been recognized by the FDA at the time that this list was created or last updated.
- There may be other genes, in addition to CYP2C19 that also influence the metabolism of the drugs listed below.
- DO NOT MAKE ANY CHANGES TO ANY MEDICATION YOU ARE TAKING WITHOUT TALKING TO YOUR HEALTH CARE PROVIDER.
Brand Name | Generic Name | Treatment Area | Use | FDA Label Recommendation |
SOMA | Carisoprodol | Rheumatology | To treat pain/stiffness from muscle spasms | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
Celexa | Citalopram | Psychiatry | To treat depression | The maximum dose should be limited to 20 mg/day in patients who are CYP2C19 poor metabolizers. |
Lexapro | Escitalopram | Psychiatry | To treat depression & anxiety | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
ONFI | Clobazam | Neurology | To treat seizures | For CYP2C19 poor metabolizers, the starting dose should be 5 mg/day and dose titration should proceed slowly according to weight. |
Plavix | Clopidogrel | Cardiovascular | To prevent blood clots | BLACK BOX WARNING: Consider alternative treatment or treatment strategies in patients identified as CYP2C19 poor metabolizers. |
Valium or Diastat |
Diazepam | Psychiatry | To treat anxiety | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
Silenor, Zonalon, Prudoxin | Doxepin | Psychiatry | Oral use to treat insomnia, depression & nerve pain. Topical use to treat itching. | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
YAZ | Drospirenone and ethinyl estradiol | Reproductive | Birth control | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
Nexium | Esomaprazole | Gastro-enterology | To treat reflux | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
VIMPAT | Lacosamide | Neurology | To treat seizures | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
Viracept | Nelfinavor | Antiviral | To treat viral infections | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
ACIPHEX | Rabeprazole | Gastroenterology | To treat reflux | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
Dilantin | Phenytoin | Neurology | To treat seizures | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
Effient | Prasugrel | Cardiology | To prevent blood clots | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
Brilinta | Ticagrelor | Cardiology | To treat reflux | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
VFEND | Voriconazole | Antifungal | To treat serious fungal infections | No specific recommendation for action based on CYP2C19 genotype is given in the drug label. |
Updated 11/11/16 |